Thesis Title: The Molecular and Physicochemical Mechanisms by which Mushroom Functional Food Products Affect Obesity, Diabetes and Neurodegeneration.

Mushrooms have been regarded as potential functional food materials due to their bioactive compounds (dietary fibre and phenolic compounds). This research will investigate the bioactive composition of 3 mushroom types (white button, oyster and shiitake) and the distribution of these compounds in the cap, stem and whole mushroom. Mushroom bioactive materials will be evaluated with regards to their potential to reduce glycaemic impact, manipulate obesity and satiety hormonal expression, and the potential influence on neurodegenerative factors.


Liwen Wang, Minxiong Pan, Chih-Yu Lo, Hui Zhao, Shiming Li, Chi-Tang Ho, Guliang Yang. (2017). Anti-fibrotic activity of polyphenol-enriched sugarcane extract in rats via inhibition of p38 and JNK phosphorylation. Food & function. DOI: 10.1039/C7FO01617D

Jinhan Wang, Liwen Wang, Chi-Tang Ho, Kunsheng Zhang, Qiang Liu, Hui Zhao. (2017). Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation. Journal of Agriculture and Food Chemistry. 65(18):3675-3683. DOI: 10.1021/acs.jafc.7b00346.

Liwen Wang, Zhiwen Yue, Mengzheng Guo, Lianying Fang, Liang Bai, Xinyu Li, Yongqing Tao, Suying Wang, Qiang Liu, DexianZhi, Hui Zhao. (2016). Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-kappaB Signaling. BioMed Research International. 1068528.

Liwen Wang, Jinhan Wang, Lianying Fang., Zuliang Zheng, Dexian Zhi, Suying Wang, Shiming Li, Chi-Tang Ho, and Hui Zhao. (2014). Anticancer activities of citrus peel polymethoxyflavones related to angiogenesis and others. BioMed Research International. 453972. DOI: 10.1155/2014/453972.

Jinhan Wang, Yitao Duan, Dexian Zhi, Guangqiang Li, Liwen Wang, Hongmei Zhang, Lichao Gu, Haihua Ruan Kunsheng Zhang, Qiang Liu, Shiming Li, Chi-Tang Ho, Hui Zhao. (2014). Pro-Apoptotic Effects of the Novel Tangeretin Derivate 5-Acetyl-6,7,8,4′-Tetramethylnortangeretin on MCF-7 breast cancer cells. Cell Biochemistry and Biophysics. 70(2):1255-63. DOI: 10.1007/s12013-014-0049-7.

Dexian Zhi, Su Liu, Li Lin, Liwen Wang, Jinhan Wang, Jing Ma, Suying Wang, Hui Zhao, Chi-Tang Ho, Ya-Fei Wang, Qiang Liu. (2014). 5-Acetyl-6,7,8,4′-tetramethylnortangeretin induces apoptosis in multiple myeloma U266 cells. Food Science and Human Wellness. 3(3-4):197-203.


Lincoln University & Tianjin University of Commerce, China